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1

Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class

Brischwein, Klaus, Parr, Larissa, Pflanz, Stefan, Volkland, Jörg, Lumsden, John, Klinger, Matthias, Locher, Mathias, Hammond, Scott A., Kiener, Peter, Kufer, Peter, Schlereth, Bernd, Baeuerle, Patrick

Journal:

Journal of Immunotherapy

Year:

2007

Language:

english

File:

PDF, 361 KB

english, 2007

2

Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/CD3-bispecific single-chain antibody construct

Patrick Hoffmann, Robert Hofmeister, Klaus Brischwein, Christian Brandl, Sandrine Crommer, Ralf Bargou, Christian Itin, Nadja Prang, Patrick A. Baeuerle

Journal:

International Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 359 KB

english, 2005

3

Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3

Bernd Schlereth, Petra Kleindienst, Iduna Fichtner, Grit Lorenczewski, Klaus Brischwein, Sandra Lippold, Antonio da Silva, Mathias Locher, Roman Kischel, Ralf Lutterbüse, Peter Kufer, Patrick A. Baeue

Journal:

Cancer Immunology, Immunotherapy

Year:

2006

Language:

english

File:

PDF, 472 KB

english, 2006

4

CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis

Michael Mølhøj, Sandrine Crommer, Klaus Brischwein, Doris Rau, Mirnaalini Sriskandarajah, Patrick Hoffmann, Peter Kufer, Robert Hofmeister, Patrick A. Baeuerle

Journal:

Molecular Immunology

Year:

2007

Language:

english

File:

PDF, 792 KB

english, 2007

5

Rund um die Praxis - Die eigene Heilpraktikerpraxis: Der Businessplan als Fundament

Year:

2010

Language:

german

File:

PDF, 530 KB

german, 2010

6

Analysis of Drug Action on Tumor Cell Metabolism Using Electronic Sensor Chips

Angela M. Otto, Martin Brischwein, Elena Motrescu, Bernhard Wolf

Journal:

Archiv der Pharmazie

Year:

2004

Language:

english

File:

PDF, 225 KB

english, 2004

7

Möglichkeiten und Grenzen der Mikrosensortechnologie in zellulärer Diagnostik und Pharmascreening

M. Brischwein, H. Grothe, A. M. Otto, J. Ressler, V. Lob, J. Wiest, B. Wolf

Journal:

Chemie Ingenieur Technik

Year:

2005

Language:

german

File:

PDF, 286 KB

german, 2005

8

Miniaturisierbare, biokompatible Gelöst- Sauerstoff-Sensoren

J. Wiest, M. Brischwein, H. Grothe, B. Wolf

Journal:

Chemie Ingenieur Technik

Year:

2005

Language:

german

File:

PDF, 134 KB

german, 2005

9

Monitoring of cellular behaviour by impedance measurements on interdigitated electrode structures

R. Ehret, W. Baumann, M. Brischwein, A. Schwinde, K. Stegbauer, B. Wolf

Journal:

Biosensors and Bioelectronics

Year:

1997

Language:

english

File:

PDF, 1.25 MB

english, 1997

10

Multiparameter techniques for non-invasive measurement of blood glucose

Carlos F. Amaral, Martin Brischwein, Bernhard Wolf

Journal:

Sensors and Actuators B: Chemical

Year:

2009

Language:

english

File:

PDF, 409 KB

english, 2009

11

Biofunctional hybrid structures—cell–silicon hybrids for applications in biomedicine and bioinformatics

Bernhard Wolf, Michael Kraus, Martin Brischwein, Ralf Ehret, Werner Baumann, Mirko Lehmann

Journal:

Bioelectrochemistry and Bioenergetics

Year:

1998

Language:

english

File:

PDF, 3.39 MB

english, 1998

12

Microelectronic sensor system for microphysiological application on living cells

W.H Baumann, M Lehmann, A Schwinde, R Ehret, M Brischwein, B Wolf

Journal:

Sensors and Actuators B: Chemical

Year:

1999

Language:

english

File:

PDF, 2.10 MB

english, 1999

13

Simultaneous measurement of cellular respiration and acidification with a single CMOS ISFET

Mirko Lehmann, Werner Baumann, Martin Brischwein, Hans-Jürgen Gahle, Ingo Freund, Ralf Ehret, Sabine Drechsler, Heiko Palzer, Martin Kleintges, Ullrich Sieben, Bernhard Wolf

Journal:

Biosensors and Bioelectronics

Year:

2001

Language:

english

File:

PDF, 484 KB

english, 2001

14

Monitoring of cellular signalling and metabolism with modular sensor-technique: The PhysioControl-Microsystem (PCM®)

Bernhard Wolf, Martin Brischwein, Werner Baumann, Ralf Ehret, Michael Kraus

Journal:

Biosensors and Bioelectronics

Year:

1998

Language:

english

File:

PDF, 963 KB

english, 1998

15

On-line control of cellular adhesion with impedance measurements using interdigitated electrode structures

R. Ehret, W. Baumann, M. Brischwein, A. Schwinde, B. Wolf

Journal:

Medical and Biological Engineering and Computing

Year:

1998

Language:

english

File:

PDF, 934 KB

english, 1998

16

Multiparametric microsensor chips for screening applications

R. Ehret, W. Baumann, M. Brischwein, M. Lehmann, T. Henning, I. Freund, S. Drechsler, U. Friedrich, M.-L. Hubert, E. Motrescu, A. Kob, H. Palzer, H. Grothe, B. Wolf

Journal:

Analytical and Bioanalytical Chemistry

Year:

2001

Language:

english

File:

PDF, 491 KB

english, 2001

17

Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Petra Lutterbuese, Klaus Brischwein, Robert Hofmeister, Sandrine Crommer, Grit Lorenczewski, Laetitia Petersen, Sandra Lippold, Antonio da Silva, Mathias Locher, Patrick A. Baeuerle, Bernd Schlereth

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 368 KB

english, 2007

18

The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct

Christian Brandl, Cornelia Haas, Sandrine d’Argouges, Tanja Fisch, Peter Kufer, Klaus Brischwein, Nadja Prang, Ralf Bargou, JoAnn Suzich, Patrick A. Baeuerle, Robert Hofmeister

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 431 KB

english, 2007

19

Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans

Maria Amann, Matthias Friedrich, Petra Lutterbuese, Eva Vieser, Grit Lorenczewski, Laetitia Petersen, Klaus Brischwein, Peter Kufer, Roman Kischel, Patrick A. Baeuerle, Bernd Schlereth

Journal:

Cancer Immunology, Immunotherapy

Year:

2009

Language:

english

File:

PDF, 672 KB

english, 2009

20

Dynamic analysis of metabolic effects of chloroacetaldehyde and cytochalasin B on tumor cells using bioelectronic sensor chips

E. R. Motrescu, A. M. Otto, M. Brischwein, S. Zahler, B. Wolf

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2005

Language:

english

File:

PDF, 327 KB

english, 2005

21

Lysis of cancer cells by autologous T cells in breast cancer pleural effusates treated with anti-EpCAM BiTE antibody MT110

Juliane Witthauer, Bernd Schlereth, Klaus Brischwein, Hauke Winter, Ilona Funke, Karl-Walter Jauch, Patrick Baeuerle, Barbara Mayer

Journal:

Breast Cancer Research and Treatment

Year:

2009

Language:

english

File:

PDF, 471 KB

english, 2009

22

Automated live cell screening system based on a 24-well-microplate with integrated micro fluidics

V. Lob, T. Geisler, M. Brischwein, R. Uhl, B. Wolf

Journal:

Medical and Biological Engineering and Computing

Year:

2007

Language:

english

File:

PDF, 292 KB

english, 2007

23

Sensor-based cell and tissue screening for personalized cancer chemotherapy

Regina Kleinhans, Martin Brischwein, Pei Wang, Bernhard Becker, Franz Demmel, Tobias Schwarzenberger, Marlies Zottmann, Peter Wolf, Axel Niendorf, Bernhard Wolf

Journal:

Medical and Biological Engineering and Computing

Year:

2012

Language:

english

File:

PDF, 550 KB

english, 2012

24

The influence of different methods of disinfection on the function of electrochemical sensors

S Herrmann, W Oelßner, H Kaden, M Brischwein, B Wolf

Journal:

Sensors and Actuators B: Chemical

Year:

2000

Language:

english

File:

PDF, 375 KB

english, 2000

25

Non-invasive measurement of cell membrane associated proton gradients by ion-sensitive field effect transistor arrays for microphysiological and bioelectronical applications

Mirko Lehmann, Werner Baumann, Martin Brischwein, Ralf Ehret, Michael Kraus, Anne Schwinde, Matthias Bitzenhofer, Ingo Freund, Bernhard Wolf

Journal:

Biosensors and Bioelectronics

Year:

2000

Language:

english

File:

PDF, 1.06 MB

english, 2000

26

Anticancer Drug-mediated Induction of Multidrug Resistance-associated Genes and Protein Kinase C Isozymes in the T-Lymphoblastoid Cell Line CCRF-CEM and in Blasts from Patients with Acute Lymphoblastic Leukemias

James F. Beck, Dorothee Brügger, Klaus Brischwein, Chao Liu, Peter Bader, Dietrich Niethammer, Volker Gekeler

Journal:

Year:

2001

Language:

english

File:

PDF, 241 KB

english, 2001

27

Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines

Prang, N, Preithner, S, Brischwein, K, Göster, P, Wöppel, A, Müller, J, Steiger, C, Peters, M, Baeuerle, P A, da Silva, A J

Journal:

British Journal of Cancer

Year:

2005

Language:

english

File:

PDF, 155 KB

english, 2005

28

Microphysiological testing for chemosensitivity of living tumor cells with multiparametric microsensor chips

Angela M Otto, Martin Brischwein, Axel Niendorf, Tobias Henning, Elena Motrescu, Bernhard Wolf

Journal:

Cancer Detection and Prevention

Year:

2003

Language:

english

File:

PDF, 173 KB

english, 2003

29

Role of Ribonucleotide Reductase and Deoxynucleotide Pools in the Oxygen-Dependent Control of DNA Replication in Ehrlich Ascites Cells

Klaus Brischwein, Michael Engelcke, Hans-Jörg Riedinger, Hans Probst

Journal:

Year:

1997

Language:

english

File:

PDF, 991 KB

english, 1997

30

Therapeutic Window of MuS110, a Single-Chain Antibody Construct Bispecific for Murine EpCAM and Murine CD3

Amann, M., Brischwein, K., Lutterbuese, P., Parr, L., Petersen, L., Lorenczewski, G., Krinner, E., Bruckmeier, S., Lippold, S., Kischel, R.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 693 KB

english, 2008

31

Staurosporine suppresses replicon initiation in mammalian cells

Volker Gekeler, Annette Wilisch, Gudrun Probst, Andrea Kugel, Klaus Brischwein, Michael Engelcke, Hans Probst

Journal:

Year:

1993

Language:

english

File:

PDF, 761 KB

english, 1993

32

Down-regulation of protein kinase Cη by antisense oligonucleotides sensitises A549 lung cancer cells to vincristine and paclitaxel

Jürgen Sonnemann, Volker Gekeler, Katrin Ahlbrecht, Klaus Brischwein, Chao Liu, Peter Bader, Cornelia Müller, Dietrich Niethammer, James F Beck

Journal:

Year:

2004

Language:

english

File:

PDF, 244 KB

english, 2004

33

Mode of cytotoxic action of T cell-engaging BiTE antibody MT110

Cornelia Haas, Eva Krinner, Klaus Brischwein, Patrick Hoffmann, Ralf Lutterbüse, Bernd Schlereth, Peter Kufer, Patrick A. Baeuerle

Journal:

Year:

2009

Language:

english

File:

PDF, 594 KB

english, 2009

34

MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

Klaus Brischwein, Bernd Schlereth, Benjamin Guller, Carola Steiger, Andreas Wolf, Ralf Lutterbuese, Sonja Offner, Mathias Locher, Thomas Urbig, Tobias Raum, Petra Kleindienst, Pauline Wimberger, Raine

Journal:

Molecular Immunology

Year:

2006

Language:

english

File:

PDF, 409 KB

english, 2006

35

Determination of dynamic doxorubicin-EC50 value in an automated high-content workstation for cellular assays

Peter Wolf, Florian Hartl, Martin Brischwein, Bernhard Wolf

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 831 KB

english, 2011

36

Analysis of the redox reaction of an archaebacterial copper protein, halocyanin, by electrochemistry and FTIR difference spectroscopy

Brischwein, Martin, Scharf, Birgit, Engelhard, Martin, Maentele, Werner

Journal:

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

37

200 POSTER Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BITE class

K. Brischwein, L. Parr, S. Pflanz, J. Volkland, J. Lumsden, M. Klinger, B. Schlereth, M. Locher, P. Kufer, P.A. Baeuerle

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 71 KB

english, 2006

38

224 POSTER Characterization of a murine EpCAM/CD3-bispecific BiTE molecule as a surrogate for preclinical development of the human EpCAM/CD3-bispecific BiTE molecule MT110

B. Schlereth, K. Brischwein, P. Lutterbuese, L. Parr, G. Lorenczewski, M. Aman, R. Kischel, P. Kufer, M. Locher, P.A. Baeuerle

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 147 KB

english, 2006

39

Self calibration of a planar dissolved oxygen sensor

Eminaga, Yazay, Brischwein, Martin, Wiest, Joachim, Clauss, Johannes, Becker, Sven, Wolf, Bernhard

Journal:

Sensors and Actuators B: Chemical

Year:

2013

Language:

english

File:

PDF, 573 KB

english, 2013

40

Mikrosensorische Systeme in der zellbiologischen Grundlagenforschung und der medizinischen Diagnostik

Martin Brischwein, Werner Baumann, Ralf Ehret, Anne Schwinde…

Journal:

Naturwissenschaften (The Science of Nature)

Year:

1996

File:

PDF, 884 KB

1996

41

Electric cell-substrate impedance sensing with screen printed electrode structures

Brischwein, Martin, Herrmann, Sigrun, Vonau, Winfried, Berthold, Frank, Grothe, Helmut, Motrescu, Elena Roza, Wolf, Bernhard

Journal:

Year:

2006

Language:

english

File:

PDF, 439 KB

english, 2006

42

Impedance sensor technology for cell-based assays in the framework of a high-content screening system

Schwarzenberger, T, Wolf, P, Brischwein, M, Kleinhans, R, Demmel, F, Lechner, A, Becker, B, Wolf, B

Journal:

Physiological Measurement

Year:

2011

Language:

english

File:

PDF, 1.65 MB

english, 2011

43

Automated platform for sensor-based monitoring and controlled assays of living cells and tissues

Wolf, P., Brischwein, M., Kleinhans, R., Demmel, F., Schwarzenberger, T., Pfister, C., Wolf, B.

Journal:

Biosensors and Bioelectronics

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

44

Functional cellular assays with multiparametric silicon sensor chips

Brischwein, M., Motrescu, E. R., Cabala, E., Otto, A. M., Grothe, H., Wolf, B.

Journal:

Year:

2003

Language:

english

File:

PDF, 822 KB

english, 2003

45

[IEEE AFRICON 2007 - Windhoek, South Africa (2007.10.26-2007.10.28)] AFRICON 2007 - The use of screen printed electrodes for the sensing of cell responses

Brischwein, Martin, Herrmann, Sigrun, Vonau, Winfried, Berthold, Frank, Grothe, Helmut, Motrescu, Elena R., Wolf, Bernhard

Year:

2007

Language:

english

File:

PDF, 1.21 MB

english, 2007

46

[IEEE IEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering - Genoa, Italy (6-9 June 2002)] Proceedings of the IEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering - Cell-silicon-hybrids for biomedical analysis and bioinformatics

Wolf, B., Brischwein, M., Grothe, H., Motrescu, E.R., Otto, A.M., Stepper, C.

Year:

2002

Language:

english

File:

PDF, 42 KB

english, 2002

47

[IEEE AFRICON 2007 - Windhoek, South Africa (2007.10.26-2007.10.28)] AFRICON 2007 - Environmental engineering using living cells as signal transducers

Wiest, J., Schmidhuber, M., Grundl, D., Brischwein, M., Grothe, H., Wolf, B.

Year:

2007

Language:

english

File:

PDF, 942 KB

english, 2007

48

[IEEE 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Osaka (2013.7.3-2013.7.7)] 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Label-free monitoring of whole cell vitality

Weiss, D., Brischwein, M., Grothe, H., Wolf, B., Wiest, J.

Year:

2013

Language:

english

File:

PDF, 704 KB

english, 2013

49

Microsensor-Aided Measurements of Cellular Signalling and Metabolism on Tumor Cells

Wolf, Bernhard, Brischwein, Martin, Baumann, Werner, Ehret, Ralf, Henning, Tobias, Lehmann, Mirko, Schwinde, Anne

Journal:

Year:

1998

Language:

english

File:

PDF, 605 KB

english, 1998

50

Bioelektronische Systeme für zelluläre Analytik und therapeutische Konzepte

Wolf, B., Baumann, W., Brischwein, M., Ehret, R., Lehmann, M., Kraus, M., Henning, T., Freund, I.

Journal:

Zeitschrift für Medizinische Physik

Year:

2000

File:

PDF, 5.62 MB

2000